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1950s smallpox vaccine passes dilution test

first_img The existence of Aventis Pasteur’s stockpile of millions of doses of frozen smallpox vaccine was publicly disclosed in March 2002. The company then offered to turn the vaccine over to the federal government, which was preparing a smallpox vaccination program for the military and some healthcare workers at the time. The JAMA report says the stockpile contains about 85 million doses. Talbot TR, Stapleton JT, Brady R, et al. Vaccination success rate and reaction profile with diluted and undiluted smallpox vaccine. JAMA 2004;292(10):1205-12 [Abstract] More than 99% of the vaccinees showed a vaccination “take,” defined as a vesicle or pustule at the site 6 to 11 days after vaccination, with no significant difference in take rates between the three dilution groups, the report says. All volunteers had induration and erythema at the inoculation site, but the areas affected were significantly smaller in women than in men. Before the disclosure of the Aventis stockpile, the nation’s supply of smallpox vaccine was only about 15 million doses (though studies have shown it can be diluted). However, the British vaccine maker Acambis has been under contract since 2001 to supply 209 million doses of a smallpox vaccine to the government. In view of the findings, the authors write, “The existing supply of approximately 85 million doses of APSV [Aventis Pasteur smallpox vaccine] can be expanded, leaving an ample stockpile of smallpox vaccine to protect the entire US population in the event widespread vaccination is imminently needed. With adequate supplies of vaccine for the population of the United States, the potential exists for sharing additional supplies with other countries as well.” Using vaccine made in 1956 and 1957, the recent study was a double-blind, randomized trial funded by the National Institute of Allergy and Infectious Diseases. Volunteers recruited at Vanderbilt, Iowa, and Cincinnati were screened for contraindications and given the vaccine at full strength or in a 1:5 or 1:10 dilution. The volunteers, who had never had a smallpox shot, were then observed in person every 3 to 5 days for 2 weeks and again at 1 and 2 months after vaccination, and were interviewed by phone after 6 months. Blood serum samples were taken before vaccination and 28 and 56 days afterward. A trial of the vaccine in 340 young adults showed it was effective when diluted to one-fifth and one-tenth of full strength, according to the report by a team of 10 researchers from Vanderbilt University, the University of Iowa, Cincinnati Children’s Hospital, and EMMES Corp. The lead author is Thomas R. Talbot, MD, MPH, of Vanderbilt University School of Medicine. In the 2 weeks after vaccination, 99.7% of the volunteers had pain or itching at or near the vaccination site. Systemic symptoms were also common: fatigue was reported by 79.1%, myalgia by 78.2%, headache by 75.0%, and fever by 21.5%. The frequency of these side effects was about the same in all three groups. A quarter of the vaccinees missed some activities because of reactions to the shot. The authors say the frequency of side effects, while not unexpected, seemed higher than that in a recent trial of lyophilized (powdered) smallpox vaccine. Sep 10, 2004 (CIDRAP News) – A test of smallpox vaccine made by Aventis Pasteur in the 1950s show it is still effective even when diluted, suggesting that the United States has more than enough vaccine for everyone, according to a report this week in the Journal of the American Medical Association. The researchers did not actively monitor the volunteers for cardiac symptoms, because the trial took place before myopericarditis emerged as a rare side effect in the US military smallpox vaccination program. However, four volunteers reported episodes of chest pain or tightness in the 2 weeks after vaccination, and one reported exercise-associated dyspnea and tachycardia. All of these symptoms resolved with rest or treatment with nonprescription drugs, the report says. Because of the number of smallpox vaccine trials coinciding with this one, serologic data for all the vaccinees were not available in time for the JAMA report. However, data were available for a subset of 109 volunteers from Vanderbilt University. By a month after vaccination, all except one of these vaccinees had developed a neutralizing antibody response. This response was significantly higher in the 1:5 dilution group than in the 1:10 group.last_img read more

Letters to the Editor for Friday, Nov. 22

first_imgCategories: Letters to the Editor, OpinionRep. Stefanik serves as an inspirationI am so proud to call Elise Stefanik my congresswoman.She has been doing a spectacular job speaking out at the impeachment hearing.Rep. Stefanik has proven herself to be well prepared, articulate and professional.She serves her constituents well by promoting lower taxes, small businesses, local farms and advocating for our military and veterans.She has been a strong supporter of the Second Amendment and our school safety.She is an amazing role model for young girls like me.I aspire to be like our congresswoman some day.I am looking forward to helping with her upcoming campaign for re-election.Meg MessittWiltonThe writer is a student at Saratoga Springs High School.Balance Adk. task force, issue permitsYour Nov. 9 editorial about protection of the Adirondacks focuses on overuse and damage to portions of our largest wilderness, the High Peaks.While the state DEC is to be credited for forming a task force to study the problem, we noticed how few wilderness advocates were appointed.Just two of 13 appointees are associated with organizations espousing wilderness protection, ostensibly a key purpose of the task force. Most appointees, eight, are state and local government employees, who should be represented but who ought not to dominate.Second, your list of High Peaks priorities mirrors that of the DEC: trail repair, redirecting hikers, enforcing parking rules, guidance for visitors. These measures, while important, have proved insufficient.They leave out a tool used in other popular wilderness areas: a permit reservation or limited entry system. The DEC would set limits on the number of people hiking off the most heavily impacted trails to the peaks. They would issue online permits up to those limits, just as DEC has done for years at state campgrounds, holding back some permits for same-day use.They would monitor and evaluate its benefits which may include less damage to trails and natural resources and greater opportunities for hikers and campers to have a true wilderness experience, free from over-congestion.Permit fees could be dedicated to wilderness trail maintenance and forest rangers. Adirondack Wild encourages DEC to test such a system in 2020.David GibsonBallston LakeThe writer is managing partner with Adirondack Wild: Friends of the Forest Preserve.More from The Daily Gazette:EDITORIAL: Urgent: Today is the last day to complete the censusFoss: Should main downtown branch of the Schenectady County Public Library reopen?EDITORIAL: Beware of voter intimidationGov. Andrew Cuomo’s press conference for Sunday, Oct. 18EDITORIAL: Thruway tax unfair to working motoristslast_img read more

Time to review currency hedges given volatility, say consultants

first_img“One thing we are clear on is making sure clients are aware of all the risks,” he told IPE. “In fixed income it’s sensible to hedge currency risks as much as possible. In equity it’s a question of measuring the risks and making sure you’re happy with them.”Trump’s victory in November’s US presidential election and the UK’s decision to leave the EU were both unpredicted, as were the reactions of financial markets, Mikulskis added.“We don’t think there’s a lot of value in pension schemes trying to call idiosyncratic events like this,” he said. “Instead we would recommend a spread of risks – don’t have too much riding on individual events.”Tim Giles, head of UK investment consulting at Aon Hewitt, said pension funds with unhedged exposure to global equities had seen “fantastic” performance in recent weeks.“‘Should I lock in those gains?’ is the natural question,” he said.Sterling’s recent weakness had led to it reaching a “reasonable” price, Giles added.“It’s time to take a view about whether or not you want to take that risk,” he said. “We’re discussing this a lot with clients. You want to take the risks for which you expect to be rewarded. If you’re not happy with the potential gains then you shouldn’t be exposed to that risk.”Andrien Meyers, senior investment consultant at JLT Employee Benefits, agreed, adding that most funds’ default position was to hedge 50% of their foreign exchange exposure to “soften” the impact of any movements.The CIO of a large corporate UK pension fund said fully hedging out all currency exposure is “rarely optimal”, as having foreign currency allocations can have a risk-reducing effect on a portfolio.The CIO, who asked not to be identified, also concurred with the importance of setting a policy on currency, and urged investors to ensure it applied to the entire portfolio.“The currency doesn’t know what asset it is hedging,” he told IPE. “You’ve got to look at it holistically.”Switzerland’s hedging lessonsIn January 2015, pension funds in Switzerland were hit by the Swiss National Bank’s sudden decision to cut the franc’s peg to the euro. At the time, Willis Towers Watson estimated that as much as CHF30bn (€27.9bn) may have been wiped off pension portfolios.However, pension funds such as AHV, BVK, and Publica all managed to mitigate much of the negative impact of the decision through currency hedging.In the UK, sterling plummeted from €1.36 to the pound at the start of January 2016 to €1.23 the day after the UK voted to leave the European Union – a decline of 9.6%. In the same period, the UK currency fell 7.5% against the dollar.By 16 January 2017, speculation about the direction and implications of the UK’s Brexit strategy had pushed the pound down to €1.14 and $1.20 – sterling’s lowest recorded level versus the dollar. The next day the currency rebounded slightly following a speech on the UK government’s plan for Brexit negotations by prime minister Theresa May.As of 23 January sterling was trading at €1.16 and $1.25 – in both cases roughly 15% lower than at the start of 2016. Pension funds should see recent volatility in sterling and other currencies as a prompt to review their hedging positions, consultants have said.A measure of weekly volatility of sterling showed expectations about the UK currency last week were at their most uncertain point since the country voted to leave the European Union.The Japanese yen has been weakening versus sterling and the dollar in recent weeks, while the Chinese renminbi is also depreciating. The US dollar, meanwhile, strengthened in the weeks following the election of Donald Trump.Given so much policy uncertainty, pension funds should make sure they are clear on their policies for currency exposure and hedging, said Dan Mikulskis, head of defined benefit pensions at Redington.last_img read more

SHEER PLEASURE SURGES TO THREE QUARTER LENGTH WIN IN $200,000 EVENING JEWEL STAKES; BAZE, D’AMATO COMBINE FOR CAL-BRED VICTORY

first_img–30– ARCADIA, Calif. (April 4, 2015)–With a dramatic late surge, trainer Phil D’Amato’s Sheer Pleasure overtook Grand Yodeler to win Saturday’s $200,000 Evening Jewel Stakes at Santa Anita by three quarters of a length. A 3-year-old California-bred filly by Birdonthewire, Sheer Pleasure was ridden by Tyler Baze and covered 6 ½ furlongs in 1:17.09.Owned by Little Red Feather Racing and RM Racing, Sheer Pleasure, who unseated her jockey after stumbling at the break of her most recent start on March 6, was off at 8-1 and paid $18.20, $9.60 and $6.20. Bred by Madera Thoroughbreds, LLC, Sheer Pleasure got her second win from four starts and with the winner’s cut of $110,000, increased her earnings to $147,450.Next to last going to the quarter pole in a field of 12 sophomore fillies bred or sired in California, Sheer Pleasure split horses five-wide turning for home and smoked home the final three sixteenths of a mile.“She kind of got lost out there,” said Baze. She was out there by herself and was so wide she almost didn’t see that horse to her inside (runner-up Grand Yodeler)…She got down and really took off that last hundred yards. I hit her twice and she just took off, really had a burst.“I just wanted to be patient today. There was a ton of speed in the race and I didn’t know how she would take dirt in her face but really after the first eighth of a mile, it didn’t bother her. It was just a matter of pulling the trigger at the right time and she’s just a nice filly.”D’Amato was encouraged by the way his filly finished and indicated she may be ticketed to a two turn race in the near future.“I think the longer, the better with this filly,” D’Amato said. “She has a lot of upside to her. I didn’t know if we were going to get there (in time). I know from training her that she gets stronger as the race gets longer. She was picking up steam and we nailed her at the very end.”Trained by Eddie Truman and ridden by Kent Desormeaux, Grand Yodeler sat a close third early, took the lead turning for home, opened up 2 ½ lengths at the furlong pole but couldn’t hold off the winner, finishing second, 4 ¼ lengths in front of Ashley’s Sassy. Off at 23-1, Grand Yodeler paid $21.60 and $12.00.Ridden by Mike Smith, Ashley’s Sassy broke awkwardly, was relegated to last after the first half mile and rallied six-wide turning for home to finish third, a half length in front of Long Hot Summer. Off at 9-1, Ashley’s Sassy paid $6.00 to show.Fractions on the race were 22.26, 45.91 and 1:10.64. EVENING JEWEL PART OF GOLDEN STATE SERIES FOR CALIFORNIA-BRED OR SIRED RUNNERSlast_img read more

Fulham v Brentford line-ups: four changes for Whites, Bees keep same team

first_imgGoalkeeper Andy Lonergan and striker Moussa Dembele both return to the Fulham line-up for the west London derby with Brentford.The Whites show four changes from the team which lost 3-0 at Nottingham Forest, with Joe Lewis, James Husband, Ben Pringle and Matt Smith making way.Ashley Richards and Luke Garbutt also return at full-back, with Ryan Fredericks pushed forward into a more advanced role.It is Stuart Gray’s first game in temporary charge of Fulham, in the guise of senior coach.Brentford are unchanged from the win over MK Dons, with Alan McCormack – who missed that game – still out through injury.John Swift, who was also absent, returns as a substitute and is on the bench alongside Jota and Josh McEachran.Fulham: Lonergan; Richards, Stearman, Ream, Garbutt; Fredericks, O’Hara, Parker, Cairney; Dembele, McCormack. Subs: Lewis, Hutchinson, Burn, Hyndman, Kacaniklic, Smith, Woodrow.Brentford: Button; Yennaris, Tarkowski, O’Connell, Bidwell; Kerschbaumer, Diagouraga; Woods, Canos, Judge; Vibe. Subs: Bonham, Barbet, McEachran, Saunders, Jota, Swift, Hofmann.Follow West London Sport on TwitterFind us on Facebooklast_img read more

Nike cuts ties with Antonio Brown after rape accusation

first_img[vemba-video id=”tv/2019/09/19/lead-brown-live-jake-tapper.cnn”]Click here if you’re having trouble viewing this video on a mobile device.(CNN) — New England Patriots wide receiver Antonio Brown no longer has an endorsement deal with Nike, the company said Thursday, more than a week after the NFL player was accused of rape.“Antonio Brown is not a Nike athlete,” a Nike spokesperson said, declining to comment on specifics. Brown took the field Sunday in his first game as a New …last_img read more

Growing support for Play Your Part

first_img19 August 2011 The International Marketing Council of South Africa (IMC) introduced its latest campaign, Play Your Part, to representatives of government departments, business and NGOs at a recent breakfast meeting in Sandhurst, Johannesburg. The campaign encourages South Africans to do whatever they can, no matter how big or small the contribution, to create a better country. It also aims to connect and celebrate citizens who are already playing their part and making an impact in their communities. Speaking at the breakfast meeting on 17 August, IMC chief executive Miller Matola said: “Play Your Part is a national movement for social change, contributing to social cohesion and national unity.”Collaboration with forgood The IMC has collaborated with forgood, an online social network with a humanitarian focus, to create a facility whereby willing South Africans can connect with each other to share stories about the work they are doing, exchange ideas for projects and secure resources. “There are amazing people doing amazing things every day, everywhere in our country, this is a platform for them to share their stories, and to celebrate great stories,” said CEO of Heartlines Garth Japhet. The online resource gives information to people who are keen on doing something in their respective areas, but do not know how to go about it. “Play Your Part will help connect people who are interested in the same things. It will also connect them with the opportunities they are looking for,” he said. Japhet added that the Play Your Part site, powered by Forgood, will also provide regular news updates and list events taking places various communities. Play Your Part enables users to create their own profiles, join the campaign and start making a difference.Business joins in Financial Times CEO Rochelle Josiah said her publication endorses the initiative and would be playing its part through some of its own projects. Michelle Gerszt, marketing executive of the Smile Foundation, spoke about how her NGO is playing its part by helping children with facial abnormalities access free corrective plastic and reconstructive surgery. “We help children with abnormalities such as cleft lips and palates, burn victims, those with facial paralysis and other conditions. The medical staff who work with us all work for free: they volunteer their time to help our young patients. They are playing their part in changing the lives of young people and their parents.” Gerszt said her organisation is proud to be part of the Play Your Part initiative as it promotes the same values as the foundation. “The work we do brings people together for the purpose of making a difference in the lives of those in need.” She added that the Smile Foundation had a skills development programme in place to equip medical teams with the necessary techniques and knowledge. “Instead of bringing in specialists from other countries, we have our own doctors and nurses trained and skilled to perform these complex surgeries. We are investing in the medical teams we work with and we support the public hospitals we work in by purchasing equipment that can be used by the departments of plastic and reconstructive surgery.” Pieter Pretorius, GM for the country’s power utility Eskom, said his company’s 49m initiative was also making a difference in South Africa. “We are proud to be associated with the IMC’s Play Your Part. The campaign speaks to the same ideas as our project: 49m is about mobilising people to play their part in building a better future for South Africa. We want to encourage people to reduce their consumption of electricity, thereby reducing our carbon footprint.” Pretorius added that people can make small changes like remembering to switch off any lights or appliances that are not in use. “It’s not about sacrificing, but rather about being considerate. The power we save today is the power we’ll need tomorrow to light our rooms, watch our televisions and boil our kettles.”Government adds its support Zeng Msimang, director of strategy and content for the Department of International Relations and Cooperation, said the Play Your Part campaign has helped the government raise funds to provide famine relief to Somalia. She added that although the initiative is a local one, the department would promote it across all countries it works in. “For us Play Your Part is about being patriotic and it starts with our diplomats. We want it to start internally with the way we treat and behave towards each other.” First published by MediaClubSouthAfrica.com – get free high-resolution photos and professional feature articles from Brand South Africa’s media service.last_img read more

Shortcuts, Secrets, Tricks, Magic Bullets, and Shiny Objects

first_imgShortcuts: There isn’t any way to produce the results you need without doing the work that producing those results requires of you. If someone is selling that there is a shortcut that is made up of you not having to do the work, then it isn’t a shortcut; it’s a recipe for failure. The only real shortcut to producing results is to learn and execute proven strategies, i.e. training, coaching, modeling successful people, etc.Secrets: Anything that is commonly called a secret is nothing more than common knowledge and the collective wisdom of the ages. Most common knowledge can safely be called secrets because most salespeople don’t execute on the fundamentals. There are no secrets; it’s just that most people aren’t willing to do what is required to produce the result they want, so it might as well be a secret.Tricks: Tricks are usually the same thing as secrets. But when they’re not, they’re usually bad ideas. They’re ideas that step just over the line when it comes to honesty, integrity, professionalism, and craftsmanship. Like when someone says, “Here is a trick to get someone to call you back.” Tricks are never a good idea.Magic Bullets: Magic bullets are the single answer to all of your problems, issues, and challenges. The idea is that if you buy the magic bullet, your sales will skyrocket. You know these because they come with the warning that if you don’t buy the magic bullet, your doomed to fail. You know in your heart that is no magic bullet. Nothing worthwhile comes easy, and nothing good is free.Shiny Objects: It’s brand new and exciting. Everybody says it’s hot. It produces breakthrough results like nothing you’ve ever seen. And then the next “next” big thing comes along. But if the last shiny object was the answer to all of your prayers, why do you continually need a new shiny object? The truth is that shiny objects are fads. They are a reframing of an old truth. Chasing shiny objects only wastes your time, time that would be invested elsewhere.The Fundamentals: There isn’t anything sexy about the fundamentals. In fact, they’re kind of boring. You know a great deal about what you need to know and what you need to do, but you don’t do what is necessary because it’s difficult to execute the fundamentals well. So you look for easy answers, like shortcuts, secrets, tricks, magic bullets, and shiny objects. But fast is slow, and slow is fast.But the path to long term success and high performance runs straight through the fundamentals. There isn’t a straighter or faster method to get where you want to go. You just have to do the work.QuestionsWhy are easy answers so seductive?What hooks you? Secrets? Tricks? Magic bullets?What is the latest shiny object that’s caught your attention? Is it really the answer or is it another fad in a long line of fads that have hooked you?Why do we avoid the fundamentals when we know, intellectually anyway, that they’re what works?last_img read more

PH spikers doing well in Japan training despite injuries

first_imgEl Nido residents told to vacate beach homes Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ “There are still more to improve on, but the talent is there,” Kawamoto told PH coach Francis Vicente.Sports Related Videospowered by AdSparcRead Next Robredo: True leaders perform well despite having ‘uninspiring’ boss PLAY LIST 02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Trump strips away truth with hunky topless photo tweet Robredo should’ve resigned as drug czar after lack of trust issue – Panelo Church, environmentalists ask DENR to revoke ECC of Quezon province coal plant LATEST STORIES FEU Auditorium’s 70th year celebrated with FEU Theater Guild’s ‘The Dreamweavers’ Mocon quietly making big impact for Red Lions National Coffee Research Development and Extension Center brews the 2nd National Coffee Education Congress Don’t miss out on the latest news and information. The team completed its final day of training in Okayama where top club mentor Akiyoshi Kawamoto singled out reserve libero Dawn Macandili.Kawamoto said the La Salle ace played beyond his expectations and is a big asset to the national team.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsMaraño hurt her ankle in the first few days of training but has rejoined the team.Lazaro may resume playing in the Kuala Lumpur Southeast Asian Games that succeeds the Asians. Good news and bad news from the national women’s team currently training in Japan.Middle blocker and assistant team captain Aby Maraño’s ankle is almost healed, but top libero Denden Lazaro’s hamstring injury might sideline her for next month’s Asians Senior Championship.ADVERTISEMENT Lacson: SEA Games fund put in foundation like ‘Napoles case’ MOST READ View commentslast_img read more