Patina Miller is heading to the big screen, and she’s ready to battle President Snow! Blackfilm.com has released two shots of the Tony winner as Commander Paylor in the highly anticipated The Hunger Games: Mockingjay – Part 1. Take a look as Miller, Jennifer Lawrence and Liam Hemsworth get ready to take on the Capitol. The film will contain many epic battle scenes, and while it’s safe to say she’ll show off her guns while doing it, we doubt there will be jazz hands. Catch The Hunger Games: Mockingjay – Part 1 in movie theaters beginning November 21. Now, what are the chances of Miller reprising her role in the eventual stage adaptation? View Comments
The Council on the Future of Vermont (CFV) was a two year project of the Vermont Council on Rural Development. Join us in a regional roll-out of the results where residents can learn about the CFV process and share their ideas and priorities for their own towns and Vermont. A series of free and open public discussions will be held around the state this summer.FIND YOUR REGIONAL MEETING BELOW!All Meeting Times are: 6pm to 7:30pmJuly 1: Island Pond, Island Pond Welcome CenterJuly 2: North Hero, Public LibraryJuly 7: Middlebury, venue TBAJuly 8: Burlington, Fletcher Free LibraryJuly 9: Rutland, Rutland Free LibraryJuly 14: Bennington, venue TBAJuly 15: Brattleboro, Marlboro Graduate CenterJune 10: Randolph, Gifford Medical Center, Conference CenterJune 11: White River Junction, Hartford High SchoolJune 16: Barre, Old Labor Party HallJune 18: St. Albans, Bellows Free AcademyJune 23: Newport, Goodrich Public LibraryJune 24: St. Johnsbury, Fairbanks MuseumJune 25: Hyde Park, Green Mountain Tech and Career CenterFor more information and updates:visit: www.futureofvermont.org(link is external) or call VCRD at 802-223-6098!
If you’re a job applicant, you should know that few things in the hiring process causes managers more anxiety than the salary negotiation.According to research from staffing firm Robert Half, the salary negotiation can make or break the entire process.When advertising and marketing executives were asked, “Which one of the following aspects of the hiring process do you find the most difficult?”, they cited the challenge of developing compensation packages and negotiating salaries as second only to attracting interest from talented people.Offering too-low of a compensation and benefits package was the #2 reason these executives lost out on hiring top applicants. (“Accepted another job offer or counteroffer” was number one). continue reading » 4SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr
Jan 3, 2007 (CIDRAP News) – California scientists report that their analysis of the medical literature has yielded data on more than 600 molecular components of influenza A viruses that trigger immune responses, findings they hope will spur the search for vaccines offering protection against multiple flu strains.Scientists at the La Jolla Institute for Allergy and Immunology (LIAI) scanned more than 2,000 scientific articles in a hunt for data on influenza A molecular structures that interact with either of two major components of the immune system: T cells and antibody-producing B cells.Writing in the Jan 2 Proceedings of the National Academy of Sciences, the researchers report that they found information on 602 such structures, called epitopes, from 13 different influenza A subtypes. These included one particular epitope that is shared by several human flu subtypes and the H5N1 avian flu virus.Flu vaccines now in use target two surface proteins, hemagglutinin and neuraminidase. Because these proteins constantly mutate, vaccines must be changed every year to match the strains expected to be circulating during the flu season. But scientists have long hoped to develop a vaccine that would target a viral protein that is “conserved,” or essentially the same, in different strains. Epitopes that different strains have in common could, scientists believe, be used to make a vaccine that would protect against multiple strains and could be used for years.”If we can find shared epitopes, it may be possible to develop an influenza vaccine with greater cross-protection for many different viruses,” Alessandro Sette, PhD, senior author of the study, commented in an LIAI news release.The authors used the Immune Epitope Database (IEDB), described as the world’s largest repository of data on immune responses to infectious agents, to search the literature for influenza A epitopes. The La Jolla institute developed the IEDB with a $25 million contract awarded by the National Institute of Allergy and Infectious Diseases (NIAID) in 2004. Sette said the IEDB collects all known antibody and T cell epitope information in one place and is available to scientists around the world (see link below).The researchers found 2,063 articles related to influenza A epitopes, of which 429 were deemed worthy of detailed examination. This led to the cataloging of 412 T cell epitopes and 190 antibody epitopes from 13 viral subtypes and 58 different strains. The analysis yielded important data but also revealed important information gaps, the researchers write.The relatively low number of antibody epitopes was surprising, the authors write, given that antibody titers are the only accepted measure of protection from flu.Only two H5N1 avian flu epitopes were found, both from a 2004 Vietnam strain of the virus. The lack of H5N1 epitope data is not surprising, given the recent emergence of the virus and the special biosecurity measures required for studying it, the researchers say.Antibody epitopes were identified from only 5 of the 10 viral proteins—most of them from hemagglutinin, neuraminidase, and M2—whereas T cell epitopes from all 10 proteins were identified. Only one antibody epitope—versus 160 T cell epitopes—was identified by studying human samples (rather than animal samples). The authors comment that interpreting epitope data from human samples is more complex because people, unlike lab animals, typically have been exposed to many flu strains over many years.Using an analysis tool developed as part of the IEDB, the authors found that a higher percentage of T cell epitopes than of antibody epitopes were shared by multiple viral strains. About 11% of T cell epitopes were 100% identical in human and avian strains, while 30% of them were 90% identical, and 50% were 80% identical. In contrast, only 2.7% of antibody epitopes were 100% identical, and less than 11% were found to be 80% identical.”In general, the results suggest that significant levels of interstrain cross-reactivity are likely for T cell epitopes, but much less so for Ab [antibody] epitopes,” the report says.Because not all antibody and T cell responses are protective, the researchers sifted their data for epitopes associated with protective immune responses in the lab. They found only 9 antibody and 9 T cell epitopes that met their criterion. Most of the protective T cell epitopes are found in both human and avian flu strains, while most of the antibody epitopes are not, they report.”However, one protective Ab epitope from the M2 protein shows appreciable conservation among the selected human influenza strains and H5N1,” the article states. “Because M2 is a relatively conserved protein, identification of protective Ab epitopes derived from this protein, as has been pointed out, holds promise for the future development of a universal influenza epitope-based vaccine.”The authors recommend research to address the gaps their analysis revealed, including more studies on antibody epitopes and efforts to identify more avian flu virus epitopes.Gregory A. Poland, MD, a flu vaccine expert at the Mayo Clinic in Rochester, Minn., applauded the report, saying it should advance the search for a flu vaccine that targets a conserved viral component and offers protection against multiple strains. He directs the Mayo Vaccine Research Group and Program in Translational Immunovirology.”If you find a wholly conserved piece of the virus that doesn’t vary much between strains and provides cross protection between [H5N1] clade 1 and clade 2 viruses, that could be very exciting and could be the basis for developing a subunit vaccine,” Poland told CIDRAP News. “You could make it quickly and in huge quantity.”He also said the report could generate some controversy, given the division of opinion among vaccine experts on whether flu vaccines should be made from whole viruses or from viral subunits. Existing evidence shows that whole-virus vaccines are more immunogenic, but there is very little experience with subunit vaccines, he said.”The vaccine world is divided into whole-virus and subunit type people,” Poland said. “I happen to believe there’s a lot of merit to the subunit and peptide approach.”Poland also praised the LIAI researchers for collecting all the influenza A epitope data into a single database and making it possible to do types of analyses that couldn’t be done before. “It does expand the database and advances the knowledge,” he said.The NIAID, which supported the LIAI research, hailed it in a news release: “The study should help scientists who are designing new vaccines, diagnostics and immune-based therapies against seasonal and pandemic influenza because it reveals in molecular detail exactly where the immune system focuses on the viruses. . . . Information on shared protective epitopes is important for developing influenza vaccines that can provide broad protection against multiple strains of the virus.”However, the agency cautioned that the identification of conserved epitopes doesn’t necessarily mean that broadly protective vaccines are possible. “What is less clear from the analysis is how cross-reactive an immune response would be to most of these conserved epitopes,” the news release states. “Further analysis may assist scientists in identifying vaccine targets that might offer broader protection and in predicting how effective a new vaccine will be.”Bui H-H, Peters B, Assarsson E, et al. Ab and T cell epitopes of influenza A virus, knowledge and opportunities. Proc Natl Acad Sci 2007;104(1):246-51 [Abstract]See also:Immune Epitope Database and Analysis Resource homepagehttp://www.iedb.org/Jan 1 LIAI news release via EurekAlerthttp://www.eurekalert.org/pub_releases/2007-01/ljif-lcw122606.php#Jan 3 NIAID news releasehttp://www.niaid.nih.gov/news/newsreleases/2007/Pages/NewDetailsImmuneSysFlu.aspxAug 25, 2005, CIDRAP News story “Acambis hopes to build a flu vaccine that lasts”
Read also: Sustainable development crucial in Indonesia’s COVID-19 recovery, experts sayIndonesia also holds non-permanent membership in two other UN bodies. Its membership on the UN Security Council will end in December while it will sit on the UN Human Rights Council for the 2020 to 2022 period.The ECOSOC is one of six principal organs of the UN and is responsible for coordinating the economic and social fields of the organization, specifically in regard to the 15 specialized agencies, eight functional commissions and five regional commissions under its jurisdiction.It consists of 54 member states, elected annually for overlapping three-year terms.This year’s election of ECOSOC members was different from previous years, as a plenary meeting was not held to prevent the spread of COVID-19.The other Asia-Pacific countries elected to the council were Japan with 185 votes and Solomon Islands with 187.Guatemala, Bolivia, Argentina and Mexico were elected to represent Latin America and the Caribbean, while Libya, Liberia, Nigeria, Madagascar and Zimbabwe were selected as representatives from Africa.Bulgaria was the only Eastern European country to secure a seat, while Austria, Germany, Portugal, France and the United Kingdom were chosen to represent Western Europe.Topics : Indonesia has secured a seat on the United Nations Economic and Social Council (ECOSOC) for the 2021 to 2023 term.The country gained 186 out of 190 votes as a representative from the Asia-Pacific region during a closed-door voting session at the UN headquarters in New York, United States, on Wednesday, the Foreign Ministry stated.It will be the 12th time Indonesia has held non-permanent membership on the council. The country has been appointed as the council’s president twice in 1970 and 2000. As a member of the council, Indonesia is committed to actively achieving the Sustainable Development Goals (SDGs).“Indonesia will double down on efforts to utilize its role to address strategic issues, especially under ECOSOC’s bodies, such as the Food and Agricultural Organization [FAO], World Health Organization [WHO], International Maritime Organization [IMO], International Civil Aviation Organization [ICAO] and International Atomic Energy Agency [IAEA],” the statement read.The ministry added that securing a seat on the ECOSOC was important for the country’s hopes to drive a post-COVID-19 economic and social recovery.Indonesia’s membership will also be important to show global leadership in the achievement of SDGs and the advancement of national programs that are in line with the global development goals.
Environmentalists say conserving existing forests and restoring damaged ones reduces the risk of flooding, stores more planet-warming carbon and protects biodiversity.Worldwide, there are about 5.5 billion hectares of forest.Countries that have pushed forward with their Bonn pledges recognize that natural solutions like forest restoration are key to meeting national policy goals such as cutting carbon emissions, and boosting land productivity and food security, said Maginnis.Earlier this year, the World Economic Forum – which dedicated its 2020 gathering in Davos, Switzerland, to climate change and sustainability – launched a platform to drive the planting of one trillion trees worldwide.It is backed by a host of public figures, including US President Donald Trump, a long-time climate change skeptic.’Decent’ jobsIn Asia, India is aiming to increase its forest area and green cover to a third of its total land area by 2030, up from about a quarter, as part of its commitment to reduce carbon emissions and meet pledges made under the Paris climate accord.China, Ethiopia, Malawi, Cameroon and Ivory Coast have also launched large-scale tree-planting efforts with some success.Maginnis said the reforestation drive could also support post-coronavirus economic recovery plans.Preliminary analysis shows that for every $1 million invested in re-planting forests, six times the amount of jobs could be created compared to stimulus measures in other sectors, such as the auto industry during the 2008 global financial crisis, he added.”There is a real potential efficiency in being able to create decent jobs,” Maginnis said.Methods used to make the Bonn Challenge a success will likely be replicated to better manage wetlands, rivers, mangroves and coastal areas in the next decade, he added.Former UN. climate chief Christiana Figueres, who oversaw the adoption of the 2015 Paris climate agreement, said the Bonn Challenge provided the evidence needed to mobilize greater investment in reviving forests.”We know that the climate change, biodiversity, health and economic crises have all converged,” she said in a statement.”The human, environmental and economic case for increasing global restoration action is key to restoring our future.” The world’s largest reforestation push, now almost a decade old, has beaten its 2020 target, as countries use their pledges to tackle national priorities including job creation, food security and climate change, researchers said on Wednesday.The Bonn Challenge – launched in 2011 by the International Union for Conservation of Nature (IUCN) and Germany – aims for 150 million hectares (371 million acres) of degraded forest land to be under restoration by 2020 and 350 million hectares by 2030.Already, 61 nations, eight states in Brazil, Mexico and Pakistan, and five environmental groups have made non-binding commitments to restore more than 210 million hectares, about six times the size of Germany, according to an IUCN progress report. Stewart Maginnis, global director of IUCN’s Nature-based Solutions Group, said the challenge had proved successful because it was about “problem-solving”, not just tree-planting.”Part of the secret sauce is that it has got a relevance to other parts of the economy and other sectors at national level,” Swiss-based Maginnis told the Thomson Reuters Foundation.For every $1 spent on forest restoration, at least $9 of economic benefits are generated, said the report, estimating that nearly $76 trillion could be gained each year from addressing land degradation.In 2019, tropical rainforests – whose preservation is considered crucial to curbing climate change – disappeared at a rate of one football pitch every six seconds, according to data from monitoring service Global Forest Watch. Topics :
French oil giant Total has decided to sell its interest in a block located offshore Brunei to Shell for $300 million. Source: TotalTotal said on Wednesday it had signed an agreement to sell its wholly owned subsidiary Total E&P Deep Offshore Borneo BV to Shell for $300 million.The subsidiary holds an 86.95% interest in Block CA1, located 100 kilometers off the coast of Brunei.Block CA1 covers 5,850 square kilometers in the deepwater areas of Brunei in water depths ranging from 1,000 to 2,750 metres. It is located about 100 kilometres northwest of the coast of Brunei Darussalam.The transaction is subject to approval by the competent authorities and is expected to close by December 2019, Total added.Total currently operates the block alongside partners Murphy Oil (8.05%) and Petronas (5%). Upon completion of this acquisition, Shell will have an 86.95% equity interest in CA1 PSA and will assume operatorship.“This transaction fits with our strategy of actively managing our portfolio and will contribute to our program to dispose of $5 billion of non-core assets over the period 2019-2020,” said Arnaud Breuillac, President Exploration & Production at Total.Also on Wednesday, Total said in its quarterly report it would continue its $5 billion asset sale program over the 2019-20 period – 1.6 B$ was completed at the end of September – and 2019 net investments should be less than $18 billion. The company recorded a decrease in its 3Q 2019 profit affected by lower oil and gas prices despite an increase in production.Commenting on the deal with Total, Managing Director for Shell Deepwater Borneo, Ivo Verstralen, said: “This transaction is consistent with Shell’s deep water strategy to deliver competitive growth from a diverse international portfolio.”Offshore Energy Today StaffSpotted a typo? Have something more to add to the story? Maybe a nice photo? Contact our editorial team via email. Also, if you’re interested in showcasing your company, product or technology on Offshore Energy Today, please contact us via our advertising form where you can also see our media kit.
MailOnline 3 February 2015We spend around a third of our lives asleep.Not only is the weekend lie in the stuff of your weekday dreams, but sleep, along with food, water and oxygen, is essential for human survival.And the amount of shut eye a person gets each night, provides a vital indicator of their overall health.But it seems some of us aren’t getting enough time between the sheets.A new study, by experts at the National Sleep Foundation (NSF) in the US, has recommended children aged four months to 17 years old need more sleep than was previously advised.Past studies have found a lack of sleep can increase a person’s risk of obesity, heart disease and diabetes, shortening life expectancy.In order to determine exactly how much sleep a person needs at each stage of their life, a team of 18 specialists from sleep, anatomy and physiology, as well as paediatrics, neurology, gerontology and gynaecology convened to form an expert panel.The scientists at the NSF in the US worked for two years to produce the most up-to-date guidance.http://www.dailymail.co.uk/health/article-2937728/How-sleep-REALLY-need-Experts-compile-definitive-snooze-chart-revealing-shut-eye-need-stage-life.html
The Blues head coach was visibly frustrated on deadline day as they were unable to bolster their attacking options, despite Lampard making it clear they needed a striker to ease the burden on Tammy Abraham. Chelsea explored deals for a number of short-term options, including Paris Saint-Germain’s Edinson Cavani and Dries Mertens, of Napoli, before deciding to wait for their top targets to become available.Advertisement Promoted ContentWhat Happens To Your Brain When You Play Too Much Video Games?5 Of The World’s Most Unique Theme Parks20 “The Big Bang Theory” Moments Only A Few Fans Knew AboutWhich Country Is The Most Romantic In The World?Here Are The Best Movies Since 1982 You Should Definitely See11 Most Immersive Game To Play On Your Table Top7 Facts About Black Holes That Will Blow Your Mind7 Ways To Understand Your Girlfriend Better2020 Tattoo Trends: Here’s What You’ll See This YearBirds Enjoy Living In A Gallery Space Created For ThemYou’ve Only Seen Such Colorful Hairdos In A Handful Of Anime7 Universities In The World With The Highest Market Value Loading… Read Also: Man Utd, Chelsea get Timo Werner transfer boost Standard Sport understands Lyon forward Moussa Dembele is currently their preferred centre-forward signing. The Ligue 1 side were unwilling to do business last month, but Dembele is expected to become available this summer. FacebookTwitterWhatsAppEmail分享 Chelsea are preparing to hand Frank Lampard a summer war chest in excess of £150million to offset his disappointment at the club’s failure to sign any players in January.
The Batesville Girl’s Varsity Tennis team defeated Rushville 5-0 on Wednesday.#1 Singles- Lydia Olsen defeated Sarah Hershberger 6-4, 6-0.#2 Singles- Erin Longstreth defeated Larissa Dunn 6-1, 6-2.#3 Singles- Julia Hunter defeated Courtney Hall 6-2, 6-0.#1 Doubles- Brooke Bradford and Kelli Hartman defeated Maddy Kasey and Sarah Schombert 6-1, 6-0.#2 Doubles- Macy Simon and Karsen Worthington defeated Bridgette Welter and Payton Brower 6-3, 6-1.In JV action, Batesville defeated Rushville 8-0. In Singles, Alana Pinckley and Rachael Rose won two matches while Audrey Weigel won one. In doubles, Grace Heppner and Anna Kick won two matches and the doubles team of Jenna Harmeyer and Audrey Weigel won one.The Varsity is now 6-1 while the JV is 7-0. Batesville will play at home tomorrow against Columbus East on Thursday for Senior Night. Match time is 5:15.Courtesy of Bulldogs Coach Mike McKinney.